Research progress of insect neuropeptide allatostatins and their analogues
Received:May 16, 2019    Download the full
DOI：10.16801/j.issn.1008-7303.2019.0052
Key Words:insect neuropeptides  allatostatins  allatostatins analogues  structure modification  structure-activity relationship  juvenile hormone  mode of action
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Author NameAffiliationE-mail
WANG Meizi Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China  
JIN Xiaoyu Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China  
ZHOU Yuanlin Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China  
YANG Xinling Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China yangxl@cau.edu.cn 
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Abstract:
      Allatostatins (ASTs) are a kind of insect neuropeptides secreted from insect brain nerve cells. ASTs can inhibit the biosynthesis and release of juvenile hormone (JH) by influencing corpora allata (CA). Given their influence on the insect growth, development, reproduction and other physiological processes, ASTs are considered as potential pest control agents. Based on a brief introduction of insect neuropeptides' potential application in the field of pest control, the discovery, classification and function of allatostatins have been reviewed in this paper. According to the recent studies on ASTs and their analogues in our research group, the research progress in the area of structure modification and optimization of allatostatins, active conformation and the structure-activity relationship of ASTs analogues and their receptor and mode of action were summarized. The outlook of ASTs and their analogues as the candidates of eco-friendly pesticide is also proposed in this review, which were expected to provide a reference for the development of novel eco-friendly pesticides.
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