Synthesis and fungicidal activity of acetamido derivatives containing piperidine thiazole moiety
Received:February 18, 2019    Download the full
DOI：10.16801/j.issn.1008-7303.2019.0045
Key Words:piperidine thiazole  acetamido derivatives  fungicidal activity  new agrochemical
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Author NameAffiliationE-mail
DING Chengrong College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China  
YIN Xu College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China  
PAN Yayun College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China  
ZHANG Guofu College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China  
WEI Jun College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China  
TAN Chengxia College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China tanchengxia@zjut.edu.cn 
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Abstract:
      In order to find novel compounds with high fungicidal activities, a series of acetamido derivatives containing piperidine thiazole moiety were designed and synthesized by the procedure of diazotization, chlorination, cyclization and condensation. Their structures were characterized by 1H NMR, 13C NMR and HRMS. Preliminary bioassay indicated that some title compounds showed good fungicidal activities and the introduction of acetamido group had positive effect on the fungicidal activity. At the concentration of 25 mg/L, compounds 7a, 7c and 7g possessed fungicidal activities against Botrytis cinereal with the inhibition rates of 68.7%, 71.6% and 67.2%, respectively. In addition, compounds 7a, 7g and 7i showed good fungicidal activities against Phytophthora infestans (Mont.) de Bary with the inhibition rate of 50.8%, 61.9% and 55.8%, respectively.
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