Studies on antifungal components in the roots of Wikstroemia chamaedaphne Meisn. |
Received:December 20, 2018 Download the full |
DOI:10.16801/j.issn.1008-7303.2019.0019 |
Key Words:Wikstroemia chamedaphne separation and identification Phytophthora infestans antifungal activity |
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Author Name | Affiliation | E-mail | HU Zhihui | College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China | | JI Zhiqin | College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China Shaanxi Province Key Laboratory Research & Development on Botanical Pesticides, Yangling 712100, Shaanxi Province, China | | WEI Shaopeng | College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China Shaanxi Key Laboratory of Phytochemistry, Baoji 721000, Shaanxi Province, China | weishaopeng@nwsuaf.edu.cn |
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Abstract: |
In this study, 12 compounds were isolated from the methanol extract of Wikstroemia chamedaphne Meisn. using a variety of separation techniques. Based on the NMR, MS and the data in literatures, they were identified as 1-hexanoic acid-2,3-stearic acid triglyceride (1), β-sitosterol (2), dodecanol (3), cis-octadeca-9-enoic acid(4), (2E)-heptyl-3-(3,4-dihydroxyphenyl) acrylate (5), (-)-pluviatolide (6), 1β-hydroxy-10β-H-guaia-4,11-dien-3-one (7), isochamaejasmin (8), neochamaejasmin B (9), stelleranol (10), glyceryl monopalmitate (11) and (+)-nortrachelogenin (12). Among them, compounds 3, 4 and 6-12 were isolated from this plant for the first time. The results of antifungal activity evaluation indicated that isochamaejasmin (8) and neochamaejasmin B (9) showed significant inhibitory effects on the mycelial growth and the spore germination of Phytophthora infestans. The EC50 values of 8 and 9 were 68.4 μg/mL and 44.9 μg/mL for the growth of P. infestans, respectively. And the EC50 values of 8 and 9 were 25.1 μg/mL and 14.0 μg/mL, respectively, for the spore germination of P. infestans. |
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