| 手性琥珀酸脱氢酶抑制剂的研究进展 |
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投稿时间：2024-07-06
修订日期：2025-01-15
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| 引用本文：宋瑞,李素贞,付继珍,等.手性琥珀酸脱氢酶抑制剂的研究进展[J].农药学学报,2025,27(1):11-24. |
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| 基金项目:山西农业大学高层次人才科研专项(2022XG19) |
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| 中文摘要:琥珀酸脱氢酶抑制剂(succinate dehydrogenase inhibitors，SDHIs)是继甲氧基丙烯酸酯类和三唑类之后的第三大类杀菌剂，因其具有广谱杀菌特性广泛用于防治各类植物的真菌性病害。目前，市场化的SDHIs杀菌剂中8种具有手性特征，本文以其为研究对象，从分离分析方法、生物活性、环境行为、生态毒性四方面对其对映体选择性进行阐述，以期为后续手性SDHIs高效绿色单体开发应用提供理论基础，为其在农业生产过程中的安全合理使用提供科学指导。 |
| 中文关键词:琥珀酸脱氢酶抑制剂 对映体 选择性 |
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| The development of chiral succinate dehydrogenase inhibitors |
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| Abstract:Succinate dehydrogenase inhibitors (SDHI) are the third largest class of fungicides after strobilurins and triazoles. Because of their broad-spectrum bactericidal properties, they are widely used to control various types of plant fungi. At present, there were eight SDHIs with chiral characters, which show enantioselectivity in many aspects. Therefore, this paper focused on these pesticides, including their enantioselective separation and analytical methodology, biological activity, environmental fate and ecological toxicity. This manuscript provides a theoretical basis for the subsequent research on the development and application of chiral SDHIs as efficient green monomers and provides scientific guidance on the safe and reasonable application of chiral SDHIs in the process of agricultural production. |
| Key words:succinate dehydrogenase inhibitors enantiomer enantioselectivity |
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