| 丙硫咪唑在烟草中的残留及消解动态 |
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投稿时间：2018-09-04
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| 引用本文：姜桦韬,尤祥伟,牛纪军,等.丙硫咪唑在烟草中的残留及消解动态[J].农药学学报,2019,21(1):105-111. |
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| 基金项目:国家重点研发计划（2016YFD0200200-5）；中国农业科学院科技创新工程（ASTIP-TRIC07） |
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| 中文摘要:为明确丙硫咪唑在烟草中的残留消解规律，制定科学合理的农药残留限量标准，采用QuEChERS与高效液相色谱-串联三重四极杆质谱（HPLC-MS/MS）联用技术检测了烟草中丙硫咪唑的残留量，并进行了实际样品检测。结果表明：在0.001~1 mg/L范围内，丙硫咪唑的质量浓度与对应的峰面积间线性关系良好，R2 > 0.998。在0.02、0.2和2 mg/kg 3个添加水平下，丙硫咪唑在鲜烟叶中的回收率为94%~97%，相对标准偏差（RSD）为1.2%~2.7%；在0.01、0.1和2 mg/kg 3个添加水平下，丙硫咪唑在干烟叶中的回收率为85%~104%，RSD为2.0%~8.1%。丙硫咪唑在干烟叶和鲜烟叶中的最低检测浓度（LOQ）分别为0.01和0.02 mg/kg。消解动态试验结果表明，丙硫咪唑在鲜烟叶中的消解半衰期为5.4~16.1 d。以有效成分90和135 g/hm2的剂量分别施用15%丙硫唑·戊唑醇悬浮剂3次，于末次施药后7 、14和21 d时，干烟叶中丙硫咪唑的残留量分别为0.14~3.04、0.33~2.20和0.17~1.85 mg/kg。推荐其残留限量为 2 mg/kg，按照农药合理准则规范使用农药，于末次施药后21 d，丙硫咪唑在干烟叶中的残留量小于2 mg/kg，残留风险水平较低。 |
| 中文关键词:丙硫咪唑 烟草 QuEChERS 高效液相色谱-串联三重四极杆质谱 残留 |
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| Residue and dissipation dynamic of albendazole in tobacco |
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| Abstract:To investigate the residue and dissipation of albendazole in tobacco and provide reference for the setting of maximum residue limit (MRL), an analytical method and a good agricultural practices (GAP) experiment of albendazole residues in tobacco were established and had been tested for samples by using QuEChERS and high performance liquid chromatography-tandem triple quadrupole mass spectrometry (HPLC-MS/MS). Good linearity between the mass concentration of albendazole and the corresponding peak area was achieved from 0.001 to 1 mg/L, with a coefficient of determination higher than 0.998. At three addition levels of 0.02, 0.2 and 2 mg/kg, the recoveries of albendazole in fresh tobacco leaves ranged from 94% to 97%, with the relative standard deviation (RSD) was 1.2%-2.7%. At three addition levels of 0.01, 0.1 and 2 mg/kg, the recovery of albendazole in cured tobacco leaves were 85%-104%, with the RSD was 2.0%-8.1%. If the lowest spiked concentration was recognized as the limit of quantitation (LOQ), the LOQs of albendazole in cured tobacco leaves and fresh tobacco leaves were 0.01 and 0.02 mg/kg, respectively. The dissipation and terminal residue levels of albendazole in tobacco demonstrated that the half-life of albendazole in fresh tobacco leaves was 5.4 to 16.1 days. When sprayed at 90 and 135 g a.i./hm2 for three times, the terminal residues of albendazole in cured tobacco leaves at the pre-harvest interval of 7, 14 and 21 days were 0.14-3.04 mg/kg, 0.33-2.20 mg/kg and 0.17-1.85 mg/kg, respectively. It is recommended that the MRLs should be 2 mg/kg. The pesticide should be used in accordance to the recommended dosage and application interval. 21 days after the last spray, the residue was less than 2 mg/kg, which demonstrated that the residual risk level was low. |
| Key words:albendazole tobacco QuEChERS high performance liquid chromatography-tandem triple quadrupole mass spectrometry (HPLC-MS/MS) residue |
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