昆虫γ-氨基丁酸受体竞争性拮抗剂的研究进展 |
投稿时间:2017-06-10
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引用本文:郑小娇,李华光,刘根炎,等.昆虫γ-氨基丁酸受体竞争性拮抗剂的研究进展[J].农药学学报,2017,19(6):665-671. |
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基金项目:湖北省教育厅科学技术研究项目(Q20171503);武汉工程大学研究生教育创新基金(CX2016081) |
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中文摘要:γ-氨基丁酸(GABA)受体(GABAR)是杀虫剂的重要作用靶标之一,目前已商品化的作用于GABA受体的杀虫剂均属于该受体的非竞争性拮抗剂(NCAs)。研究表明,GABA受体竞争性拮抗剂(CAs)的结合位点与作用机制有别于非竞争性拮抗剂,但二者具有相似的功能,均有杀虫活性。因此,GABA受体竞争性拮抗剂也具有开发成杀虫剂的潜力,但目前竞争性拮抗剂类杀虫剂还处于研究阶段。本文对近十年来昆虫GABA受体竞争性拮抗剂的相关研究进行综述,希望引起农药研究者的关注。 |
中文关键词:昆虫 γ-氨基丁酸受体 竞争性拮抗剂 杀虫活性 研究进展 |
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Research progress of insect γ-aminobutyric acid receptor competitive antagonists |
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Abstract:γ-Aminobutyric acid (GABA) receptor (GABAR) is an important target of insecticides. Up to date, all the commercially available GABAR-targeting insecticides are GABAR noncompetitive antagonists (NCAs). Competitive antagonists (CAs) of GABARs are potential insecticides, as they have similar functions to NCAs but different binding sites and mechanisms of action. Both CAs and NCAs exhibited insecticidal activities. However, the CA-insecticides are still in the research stage at present. Here, we review the latest research progress of insect GABAR CAs in the recent decade and hope to attract the attention of pesticide researchers. |
Key words:insects GABA receptors competitive antagonists insecticidal activities research progress |
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