| 基于避蚊胺/β-环糊精/O-羧甲基壳聚糖亲水性纳米胶囊载药及缓释性能研究 |
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投稿时间：2016-12-05
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| 引用本文：刘月华,季金苟,郭红霞,等.基于避蚊胺/β-环糊精/O-羧甲基壳聚糖亲水性纳米胶囊载药及缓释性能研究[J].农药学学报,2017,19(4):528-532. |
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| 基金项目:国家自然科学基金资助项目（213751569） |
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| 中文摘要:为了改善避蚊胺（diethyltoluamide，以下简称DEET）在水中的溶解度，首先采用饱和溶液法制备了避蚊胺/β-环糊精（diethyltoluamide/β-cyclodextrin，以下简称DEET/β-CD）包合物，其结构通过差示扫描量热仪（DSC）和X-射线衍射仪（XRD）表征；再采用离子交联法，以氯化钙为交联剂，制备了避蚊胺/β-环糊精/O-羧甲基壳聚糖（diethyltoluamide/β-cyclodextrin/O-carboxymethyl chitosan，以下简称DEET/β-CD/O-CMC）亲水性纳米胶囊，用紫外-可见分光光度计（UV）、激光粒度分析仪和扫描电子显微镜（SEM）考察其理化性质；最后，考察包合物和纳米胶囊的缓释性能。结果表明：DEET与β-CD以物质的量之比1：1进行了包合，β-CD的加入使DEET的溶解度增加约27倍，该纳米胶囊的包封率为（79.93±2.08）%，载药量为（12.11±0.09）%，纳米胶囊呈椭圆形，平均粒径为（230.50±11.34）nm，Zeta电位为（–19.08±0.99）mV，PDI为0.055。在Tris-HCl（pH=7.4）缓冲液中释放试验显示，DEET/β-CD/O-CMC亲水性纳米胶囊比DEET/β-CD包合物有更好的缓释性能，24 h累积释放率分别为27.04%和38.10%。 |
| 中文关键词:避蚊胺 β-环糊精 O-羧甲基壳聚糖 包合物 纳米胶囊 缓释性能 |
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| Preparation and sustained-release of β-cyclodextrin/O-carboxymethyl chitosan nanocapsules loaded with hydrophobic diethyltoluamide |
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| Abstract:To improve water solubility of diethyltoluamide (DEET), DEET/β-cyclodextrin (DEET/β-CD) inclusion compound was prepared by homogeneous coprecipition method. Differential scanning calorimetry (DSC) and XRD were used for the characterization of the inclusion compound. Then DEET/β-CD/O-CMC nanocapsules were prepared via a cross-linking reaction. DEET/β-CD/O-CMC nanocapsules were determined by UV spectrophotometer, mastersizer and SEM. Finally, the drug release property of DEET/β-CD and DEET/β-CD/O-CMC was studied. An inclusion complex was formed in 1:1 molar ratio. DEET solubility in the water was improved 27 times by introducing β-CD into the system. And the encapsulation efficiency and loading capacity of the prepared nanocapsules were (79.93±2.08) % and (12.11±0.09) %, respectively. The nanocapsules were oval in shape with average particle sizes of (230.50±11.34) nm, Zeta potential of (–19.08±0.99) mV, and PDI of 0.055. Release studies in Tris-HCl (pH = 7.4) evidenced β-CD/O-CMC nanocapsules have better sustained-release effect than DEET/β-CD. The DEET in DEET/β-CD/O-CMC and DEET/β-CD was released 27.04% and 38.10% within 24 h, respectively. |
| Key words:DEET β-cyclodextrin O-carboxymethyl chitosan inclusion compound nanocapsules sustained-release |
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