| 杀虫剂fluralaner及其衍生物的生物效应和毒理学研究进展 |
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投稿时间：2014-12-22
修订日期：2015-03-30
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| 引用本文：赵春青,韩召军,唐涛.杀虫剂fluralaner及其衍生物的生物效应和毒理学研究进展[J].农药学学报,2015,17(3):251-256. |
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| 基金项目:国家公益性行业(农业)科研专项(201303017). |
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| 中文摘要:新型异(口恶)唑啉类杀虫剂fluralaner通过干扰γ-氨基丁酸(GABA)门控氯离子通道发挥作用。作为新型高效GABA门控氯离子通道干扰剂,与环戊二烯类、苯基吡唑类和大环内酯类杀虫剂相比,fluralaner在分子结构、作用位点、选择性以及交互抗性等方面均有显著差异。本文综述了fluralaner及其衍生物的研发、毒性、防治范围以及作用机理等,并预测了其应用前景。 |
| 中文关键词:fluralaner GABA门控氯离子通道 生物效应 毒理学 研究进展 |
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| Research progress on bioeffect and toxicology of insecticide fluralaner and its derivatives |
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| Abstract:Fluralaner acts as a novel type of isoxazoline insecticides by interfere with γ-aminobutyric acid(GABA) gated chloride channel. It displays remarkable differences in molecular structure, site of action, selectivity and cross-resistance comparing to cyclodience, phenylpyrazole and macrolides insecticides which have similar mode of action in interfering with GABA gated chloride channel. The invention, toxicity, insecticidal spectrum and mechanism of fluralaner were summarized. The prospect of fluralaner and isoxazoline insecticides were also included. |
| Key words:fluralaner GABA gated chloride channel bioeffect toxicology research progress |
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